EPISODE · May 9, 2026 · 18 MIN
936-致幻剂通过血清素受体改变神经血管耦合
from 聊聊Sci
这项研究揭示了幻觉类显微物质对大脑神经血管耦合（NVC）的显著干扰。通过对人类及小鼠的成像分析，研究人员发现赛洛西宾（Psilocybin）与DOI等药物会使神经元活动与血氧水平信号产生脱节。实验表明，这类药物不仅改变了大脑的功能连接性测量，还通过激活5-HT2A受体直接影响血管舒缩。这种神经信号与血流动力学信号的解耦意味着，仅依赖血液指标的传统神经成像技术可能无法准确反映大底层的神经真实状态。因此，该研究提醒科研人员在利用fMRI等血氧检测手段评估药物疗效时必须保持审慎。References:Padawer-Curry J A, Krentzman O J, Kuo C C, et al. Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function[J]. Nature neuroscience, 2025: 1-14.前往小宇宙评论区与主播互动
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936-致幻剂通过血清素受体改变神经血管耦合
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