EPISODE · May 20, 2026 · 5 MIN
95% of botanical ingredients are standardized on the wrong compound
from NutraSift: The nutraceutical innovation podcast · host Siftlink SA
Curcumin (standardized on total curcuminoids, not fractions). Ashwagandha (total withanolides, not specific ones). Boswellia (AKBA only, ignoring 4 other boswellic acids). Echinacea (chicoric acid, not alkamides). Ginseng (total ginsenosides, not specific ones).Silymarin (total complex, not silybin A vs B). The standardization method was designed for quality control, it was never intended to capture mechanism specificity. Every ingredient standardized on "total X%" is a transformation opportunity for whoever maps the fractions.Publications of interest:https://pmc.ncbi.nlm.nih.gov/articles/PMC4961437/https://pmc.ncbi.nlm.nih.gov/articles/PMC2488332/https://pmc.ncbi.nlm.nih.gov/articles/PMC2570109/
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95% of botanical ingredients are standardized on the wrong compound
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