958-人皮肤单细胞空间转录组解剖图谱

这份研究通过 MERFISH 单细胞空间转录组技术，构建了涵盖人体 15 个解剖部位、约 120 万个细胞的首个皮肤空间全景图谱。科研人员精确识别出 45 种细胞亚型，并揭示了皮肤在不同部位展现出的高度规律性的细胞组成与空间密度特征。研究定义了十个多细胞邻域，重点解析了维持皮肤稳态的血管周围邻域及其在免疫串扰中的核心作用。通过对比健康与疾病样本，该图谱进一步揭示了致病活动的解剖分区现象，为深入理解皮肤生物学及临床精准治疗提供了关键的分子与空间架构。References:Restrepo P, Wilder A, Houser A, et al. Single-cell spatial transcriptomic analysis of human skin anatomy[J]. Nature Genetics, 2026: 1-13.前往小宇宙评论区与主播互动

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958-人皮肤单细胞空间转录组解剖图谱

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