EPISODE · May 12, 2026 · 15 MIN
960-小鼠胚胎器官发生时空转录组图谱
from 聊聊Sci
该研究利用 Slide-seq 空间转录组技术，构建了小鼠胚胎发育关键阶段（E8.5至E9.5）的高分辨率分子图谱。研究团队开发了名为 sc3D 的计算工具，能够将二维切片数据重建成三维“虚拟胚胎”，从而实现对基因表达模式的定量分析。通过这一框架，科学家们发现了神经管发育过程中此前未被标注的新基因，并详细刻画了器官发育初期的空间表达动态。此外，该研究还分析了 Tbx6 突变体胚胎中出现的“异位”神经管，揭示了其独特的转录特征。总体而言，这项工作为探究胚胎结构的空间演变和发育缺陷提供了强有力的实验与计算平台。References:Sampath Kumar A, Tian L, Bolondi A, et al. Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis[J]. Nature Genetics, 2023, 55(7): 1176-1185.前往小宇宙评论区与主播互动
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