962-调控肠-肝-脑轴代谢的工程共生菌

这份研究展示了通过基因工程技术改造的植物乳杆菌，能够有效调节肠-肝-脑轴的代谢紊乱，从而治疗肝性脑病。研究人员设计了两种菌株：一种可吸收氨并合成支链氨基酸，另一种则能增强谷氨酰胺的利用以抑制氨的产生。在动物模型中，这些工程菌显著降低了血液与大脑中的氨含量，并改善了焦虑及认知功能障碍。相比临床常用药物利福昔明，该疗法在保持肠道菌群多样性方面表现更优，且在停药后可被迅速清除。这一进展证明了活体生物治疗药物作为可编程平台，在恢复人体代谢平衡和治疗复杂神经疾病方面的巨大潜力。References:Aggarwal N, Shen H, Lee L T, et al. Engineered commensals for metabolic modulation of the gut-liver-brain axis[J]. Cell, 2026.前往小宇宙评论区与主播互动

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