EPISODE · May 14, 2026 · 25 MIN
966-QuadPE：高效可编程的大片段基因组插入技术
from 聊聊Sci
这项研究介绍了一种名为 QuadPE 的新型基因编辑技术，旨在实现大片段 DNA 的精准、高效整合。研究人员通过设计一种 四重 pegRNA 策略，协调基因组端和供体端的末端衔接，能够将长达 26 kb 的基因片段定向插入多种人类和非人类细胞中。与现有的重组酶或转座子系统相比，QuadPE 在处理大尺寸负载时表现出更高的整合效率，且无需产生 双链断裂。该系统在非分裂细胞（如成熟神经元）和人类初级 T 细胞中均能保持高活性，展示了巨大的临床应用前景。此外，基因组范围内检测证实该技术具有极低的脱靶整合风险，确保了编辑的安全性与精确性。References:Shi Y, Ding Z, Wu Y, et al. Quadruple pegRNA enables programmable and efficient large genomic insertion[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
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966-QuadPE：高效可编程的大片段基因组插入技术
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