970-哺乳动物着床后胚胎与蜕膜的整体空间甲基化图谱

这项研究介绍了一种名为 SmC-seq 的创新微流控技术，首次实现了在保留组织空间位置信息的同时，进行高分辨率的全基因组DNA甲基化测序。科研人员利用该技术详细绘制了小鼠胚胎植入后的空间表观遗传图谱，揭示了胚胎组织与母体子宫组织在发育过程中截然不同的空间异质性和动态演变规律。研究发现，胚胎内细胞群衍生的组织呈现出清晰的甲基化梯度，而母体蜕膜组织中特定区域的低甲基化状态则与营养供应细胞的增殖及功能密切相关。通过整合空间转录组数据，该研究进一步阐明了DNA甲基化如何通过调控特定基因表达，进而影响胚胎器官发育和母胎界面的物质交换。总之，SmC-seq 为研究复杂组织在发育与疾病中的表观基因组组织架构提供了强有力的工具，填补了空间化DNA甲基化分析的技术空白。References:Shan X, Tang Y, Hu J, et al. Spatial 5mC-seq profiling of embryos and decidua after implantation in mammals[J]. Nature Methods, 2026: 1-11.前往小宇宙评论区与主播互动

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970-哺乳动物着床后胚胎与蜕膜的整体空间甲基化图谱

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