EPISODE · May 15, 2026 · 18 MIN
971-阿尔茨海默病小胶质细胞中的体细胞癌变变异
from 聊聊Sci
这项研究揭示了体细突变，尤其是与克隆性造血相关的癌症驱动基因变异，在阿尔茨海默病患者的大脑中显著增加。这些突变主要存在于小胶质细胞样巨噬细胞中，并通过克隆扩张使这些免疫细胞转变为促炎和促增殖状态。研究人员通过单细胞测序和诱导多能干细胞实验证实，这些变异会诱发与疾病相关的神经炎症特征。这一发现表明，源自血液或骨髓的突变免疫细胞可能浸润大脑，从而加速了神经退行性病变的进程。该成果为理解阿尔茨海默病的发病机制提供了全新视角，并为开发针对免疫克隆演化的治疗方案开辟了可能。References:Huang A Y, Zhou Z, Talukdar M, et al. Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states[J]. Cell, 2026.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
971-阿尔茨海默病小胶质细胞中的体细胞癌变变异
0:00
18:09
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 18 minutes long.
When was this 聊聊Sci episode published?
This episode was published on May 15, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!