EPISODE · May 15, 2026 · 16 MIN
972-热应激引发的皮肤-下丘脑轴代谢功能障碍研究
from 聊聊Sci
这篇文章通过动物实验和临床队列研究，揭示了热应激导致长期代谢功能障碍的生理机制。研究发现，高温刺激会促使皮肤分泌KLK14蛋白，该蛋白经血液进入大脑，诱导下丘脑LRRC7⁺星形胶质细胞产生持久的“热记忆”表观遗传重塑。这种重塑后的细胞会通过分泌GABA抑制附近的PVNOXT神经元，进而削弱交感神经对脂肪的支配，导致内脏脂肪堆积和肥胖。此外，研究证实补充维生素A能有效减少KLK14的分泌，显著缓解小鼠和人类因热应激引起的代谢受损。该成果强调了全球变暖正通过这一“皮肤-下丘脑轴”加剧慢性代谢疾病的流行。References:Zhou H Y, Feng X, Wen J, et al. A skin-hypothalamus axis couples heat stress and metabolic dysfunction[J]. Cell, 2026.前往小宇宙评论区与主播互动
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972-热应激引发的皮肤-下丘脑轴代谢功能障碍研究
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