EPISODE · May 15, 2026 · 21 MIN
973-肌细胞巨型转录本的核外膜芽生转运机制
from 聊聊Sci
该研究揭示了肌肉细胞在发育过程中一种非典型的核输出机制。研究发现，当成肌细胞分化为肌管时，细胞核内会产生由内核膜形成的凸起结构，即核封套芽生（NEB），用以转运体积过大而无法通过传统核孔复合物的巨型肌节转录本（如titin和nebulin mRNA）。实验证明，核芽内包含腔内囊泡，且其形成过程受到UIF蛋白的精确引导，负责将大型mRNA货物定向运输至芽生位点。此外，细胞利用ESCRT-III膜重构复合体驱动这些载有货物的囊泡完成出芽与剪切。这一发现不仅打破了核孔是核输出唯一通道的传统认知，也为理解特化细胞如何处理超长遗传信息提供了重要的分子生物学依据。References:Zaganelli S, Meehl J B, Abrisch R G, et al. Nuclear envelope budding enables export of large transcripts in muscle cells[J]. Cell, 2026.前往小宇宙评论区与主播互动
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973-肌细胞巨型转录本的核外膜芽生转运机制
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