974-人羊膜发育首孕季单细胞图谱

这项研究利用单细胞转录组学技术，首次构建了人类妊娠早期羊膜发育的详尽图谱。研究者从发育第5至9周的样本中识别出上皮、间充质和巨噬细胞等六大主要谱系，并发现了特殊的羊膜外胚层细胞。通过追踪细胞命运，该报告揭示了上皮—间充质转化（EMT）等动态重塑过程，以及驱动组织生成的复杂细胞间信号通讯网络。此外，研究还将人体数据与非人灵长类及干细胞模型进行了对比，指出不同体外模型所模拟的发育阶段存在差异。这些发现不仅阐明了羊膜在胚胎保护和免疫调节中的生物学功能，也为其在再生医学中的临床应用提供了理论依据。References:* Hu W, Sancho-Serra C, Gantner C W, et al. Atlas of amnion development during the first trimester of human pregnancy[J]. Nature cell biolog...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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974-人羊膜发育首孕季单细胞图谱

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