976-Microtubule Architecture in YAP/TAZ Mechanotransduction

This research identifies microtubule architecture as a central regulator of cellular mechanotransduction, specifically influencing the YAP/TAZ signaling pathway. The study demonstrates that mechanical forces cause microtubules to reorganize from a cage-like structure into a radial array centered at the nucleus. This shift facilitates the degradation of AMOT, a protein that acts as a mechanical rheostat by sequestering YAP/TAZ in the cytoplasm when cells are in a "mechano-OFF" state. By utilizing the centrosomal proteasome, the cell effectively removes these inhibitors to allow for nuclear entry of YAP/TAZ and subsequent gene expression. The authors further establish a mechanical continuum involving F-actin stress fibers and the nuclear envelope that coordinates this cytoskeletal restructuring. Ultimately, the research highlights how Hippo signaling and oncogenic pathways can disrupt this checkpoint to drive tumor growth.References:Vanni G, Citron A, Suli A, et al. Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling[J]. Nature Cell Biology, 2025, 27(10): 1725-1738.前往小宇宙评论区与主播互动