EPISODE · May 16, 2026 · 16 MIN
976-微管架构与AMOT稳定性在力学信号转导中的调控机制
from 聊聊Sci
这篇文章揭示了微管结构在细胞机械信号转导中的核心作用，并阐明了其如何通过Hippo信号通路调控YAP/TAZ的活性。研究发现，当细胞处于机械激活状态时，微管会从核周笼状结构重组为以中心体为核心的放射状阵列。这种结构的转变会促使AMOT蛋白（一种将YAP/TAZ截留在细胞质中的抑制因子）转运至中心体附近并被蛋白酶体降解。通过这种方式，微管架构将细胞骨架重组与蛋白质稳定性控制联系在一起，实现了对细胞生长的精准调控。此外，研究还指出Ras癌基因会破坏这一机械检查点，从而通过调控AMOT的稳定性来驱动肿瘤发生。References:Vanni G, Citron A, Suli A, et al. Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling[J]. Nature Cell Biology, 2025, 27(10): 1725-1738.前往小宇宙评论区与主播互动
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