978-LBR与LAP2介导异染色质在核外周的系留

这项研究通过对多种人类及小鼠细胞系的研究，揭示了核膜蛋白 LBR 和 LAP2 在维持细胞核内异染色质边缘锚定中的关键作用。实验表明，当同时缺失这些关键的连接蛋白以及 A 型核纤层蛋白时，原本紧贴核膜的异染色质会发生全球性的脱落并向核内部重新定位。这种核空间结构的剧烈改变并非无害，它会导致三维基因组组织架构的紊乱以及抑制性表观遗传修饰（如 H3K27me3）的显著减少。长期缺乏这些结构支撑会引发大规模的基因表达失调，甚至激活抗病毒固有免疫反应。最终，这些研究结果证明了异染色质在核周的准确定位对于维持基因组稳态和正常的细胞命运决定具有不可或缺的功能意义。References:* Lewis R, Sinigiani V, Maziak N, et al. LBR and LAP2 mediate heterochromatin tethering to the nuclear perip...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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