EPISODE · May 16, 2026 · 22 MIN
979-谱系转录因子约束黏连蛋白驱动癌基因多增强子调控
from 聊聊Sci
这篇文章探讨了谱系决定转录因子（如 EBF1 和 TCF1）如何通过调控染色质折叠来驱动癌基因的表达。研究人员利用时间分辨成像和单分子追踪技术发现，这些因子在增强子处充当凝聚素（cohesin）的渗透屏障，从而限制环挤压过程。这种机制促使多个增强子和启动子在空间上向局部拓扑中心聚集，形成利于相互作用的物理结构。在套细胞淋巴瘤和 T 细胞白血病模型中，这种空间重组对于MYC和BCL2等关键癌基因的多增强子协同调控至关重要。研究证明，转录因子的缺失会直接破坏这种三维空间布局，进而抑制癌细胞的生存与增殖。References:Zhou Y, Jay A, Burget N, et al. Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation[J]. Nature cell biology, 2026, 28(1): 149-165.前往小宇宙评论区与主播互动
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979-谱系转录因子约束黏连蛋白驱动癌基因多增强子调控
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