EPISODE · May 17, 2026 · 12 MIN
982-睾丸巨噬细胞通过线粒体转移维持雄激素合成
from 聊聊Sci
这项研究揭示了雄性哺乳动物睾丸中间质细胞（LCs）与巨噬细胞（tMacs）之间存在一个复杂的线粒体转移网络，对维持睾丸激素合成至关重要。研究发现，雄性激素的产生伴随着严重的线粒体损耗，间质细胞会通过细胞外囊泡向CD206hi巨噬细胞排放受损的线粒体，这一过程依赖于TREM2受体进行清除。与此同时，间质细胞利用VCAM1分子从MHCIIhi巨噬细胞中获取功能正常的线粒体，以补偿能量需求并提升睾酮产量。实验证明，该转移网络的任何环节受阻都会导致睾酮合成减少，进而损害雄性的生殖健康、肌肉力量和运动耐力。此外，这种细胞间的线粒体互助机制会随着年龄增长而衰退，这为理解男性性腺功能减退提供了新的科学视角。References:Xia K, Zhang S, Peng H, et al. An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis[J]. Nature Cell Biology, 2026: 1-18.前往小宇宙评论区与主播互动
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982-睾丸巨噬细胞通过线粒体转移维持雄激素合成
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