EPISODE · May 17, 2026 · 18 MIN
983-基于光电关联显微技术的纳米级脂质分布成像研究
from 聊聊Sci
这份研究介绍了一项名为 Lipid-CLEM 的创新技术，旨在攻克纳米尺度下生物膜脂质可视化的难题。研究人员结合了近天然的脂质探针与切片点击化学标注，开发出一种优化后的光电相关显微技术（CLEM）工作流。该方法利用高压冷冻和不同性质的树脂（如 HM20 和 K11M），能够精确测量特定脂质在三维超微结构中的分布情况。实验揭示了神经鞘磷脂（SM）在早期内体中的主动分选机制，证明其在管状结构与囊泡间的密度存在显著差异。这项技术打破了以往仅能观察蛋白质空间组织的局限，为研究脂质在细胞信号传导及运输中的功能提供了全新的实验手段。References:Lennartz H M, Khan S, Leng W, et al. Visualizing suborganellar lipid distribution using correlative light and electron microscopy[J]. Nature Cell Biology, 2026: 1-10.前往小宇宙评论区与主播互动
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983-基于光电关联显微技术的纳米级脂质分布成像研究
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