EPISODE · May 17, 2026 · 21 MIN
986-人类围原肠胚三胚层圆盘模型
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这份研究报告介绍了一种名为PTED的人类围原肠胚期三胚层胚盘类器官模型。该模型完全由人类多能干细胞诱导而成，无需基因转染，成功模拟了人类早期发育中关键的三胚层结构。它不仅具备背侧的羊膜状结构和腹侧的卵黄囊状结构，还展现了造血前体细胞的产生。研究证明，该模型中的胚胎与胚外组织均源自原肠运动样细胞，揭示了原肠期上胚层具有分化为胚外谱系的潜力。PTED类器官为在伦理限制较少的情况下探究人类早期发育的自我组织原理提供了重要工具。References:Sun S, Zheng Y, Kim Y S, et al. A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion-and yolk sac-like structures[J]. Nature Cell Biology, 2026: 1-17.前往小宇宙评论区与主播互动
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986-人类围原肠胚三胚层圆盘模型
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