EPISODE · May 17, 2026 · 19 MIN
987-纵向骨髓生态位对白血病干细胞的调控
from 聊聊Sci
这项研究揭示了白血病干细胞（LSCs）在骨髓中的空间分布如何决定其存活与致病能力。研究发现，处于静止期的白血病干细胞主要聚集在骨髓的干骺端，一旦这些细胞被驱赶至中央骨髓，它们便会失去干性并启动凋亡。这种空间定位受控于由DPP4、CXCL12和GPC3共同构建的三级趋化因子梯度轴。通过抑制DPP4酶的活性，可以有效逆转这种梯度，从而将白血病细胞困在骨髓内并诱导其衰竭，减少病情复发与扩散。该发现为利用现有的FDA批准药物开发新型急性髓系白血病疗法提供了科学依据。References:Wang C, Pan Y, Dong R, et al. Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour[J]. Nature Cell Biology, 2026: 1-13.前往小宇宙评论区与主播互动
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987-纵向骨髓生态位对白血病干细胞的调控
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