EPISODE · May 17, 2026 · 21 MIN
989-全基因组测序揭示肿瘤微生物组图谱
from 聊聊Sci
这份研究通过建立全新的 PathSeq-T2T 计算机分析管道，对超过一万六千个肿瘤基因组进行了深度剖析，构建出高分辨率的癌症微生物群图谱。研究人员利用完整的 T2T 人类参考基因组实现了精准的宿主过滤与去污染，发现大多数癌症在排除背景干扰后并无显著的微生物特征。然而，口腔及消化道肿瘤却承载着由细菌、真菌、病毒、古菌及原虫组成的复杂多界微生物群落。这些微生物的分布不仅因解剖部位和肿瘤亚型而异，更与肿瘤突变负荷 (TMB) 呈现显著正相关。此外，研究还揭示了嗜粘蛋白阿克曼氏菌在早发性大肠癌中的缺失，为探索微生物与宿主基因组及临床表型之间的联系提供了重要依据。References:Dohlman A B, Mjelle R, Wood H M, et al. Biodiversity and biogeography of the multi-kingdom cancer microbiome[J]. Cancer Research, 2026, 86(7_Supplement): 4901-4901.前往小宇宙评论区与主播互动
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989-全基因组测序揭示肿瘤微生物组图谱
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