EPISODE · May 17, 2026 · 19 MIN
990-分子胶抑制剂KRAS耐药机制研究
from 聊聊Sci
这份研究探讨了癌细胞如何对新型 RAS 抑制剂 daraxonrasib 产生耐药性。通过对临床患者样本和临床前模型的分析，研究人员发现特定基因突变会破坏“分子胶”复合体的形成，从而使药物失效。其中，KRAS Y64 突变通过减弱药物与蛋白的结合力产生抗性，而 KRAS Y71 和低活性的 BRAF 突变则通过增强 RAS 与下游效应因子 RAF 的结合，使其难以被药物驱离。研究阐明了这些突变如何协同干扰合成复合体的稳定性，并导致致癌信号通路的持续激活。最后，作者针对这些耐药机制，开发并验证了新型抑制剂及联合用药方案，为改善 RAS 驱动型癌症的疗效提供了机械学蓝图。References:Sang B, Ye L, Fu Z ... Disrupted molecular glue complex drives RAS inhibitor resistance. Cell, 2026; 0前往小宇宙评论区与主播互动
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990-分子胶抑制剂KRAS耐药机制研究
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