EPISODE · May 18, 2026 · 21 MIN
993-小鼠嗅觉系统的空间结构与社会气味检测
from 聊聊Sci
这项研究利用 MERFISH 空间转录组技术，为小鼠的主嗅觉系统绘制了一份极其详尽的分子图谱。研究人员全面量化了约 1100 种嗅觉受体在鼻上皮中的分布，发现感觉神经元呈现出由中心向外周以及从表层向基底分布的空间梯度。这些上皮梯度通过轴突精准投射，在嗅觉球中转化为特定的背腹和前后轴排列。通过结合神经活动标记物，研究揭示了捕食者、同类及幼崽等社会性气味如何激活特定的空间域。该成果不仅揭示了嗅觉感知的拓扑逻辑，还发现了母性经验能增强特定受体对幼崽气味的敏感度。References:Bintu B, Isogai Y, Jenie I, et al. Spatial organization and detection of social odors in mouse primary olfactory system[J]. Cell, 2026.前往小宇宙评论区与主播互动
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993-小鼠嗅觉系统的空间结构与社会气味检测
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