EPISODE · May 18, 2026 · 15 MIN
995-HOTSCRAMBL：调控造血干细胞自稳态的长链非编码RNA
from 聊聊Sci
这项研究通过人类遗传学分析，发现并命名了一种名为 HOTSCRAMBL 的新型长链非编码 RNA。研究指出，该非编码 RNA 位于 HOXA 基因簇内，通过招募剪接因子 SRSF2 来促进 HOXA9 的有效剪接与表达。特定的遗传变异 rs17437411 会改变该 RNA 的二级结构，进而抑制造血干细胞的自我更新并诱导其分化。这种遗传变异虽然会导致血细胞计数轻微下降，但能显著降低克隆性造血和多种血液癌症的发病风险。在白血病模型中，干扰 HOTSCRAMBL 的功能可抑制癌细胞增殖，为治疗 HOXA 驱动型白血病提供了新的分子靶点。总之，该发现揭示了人类进化过程中微调造血功能的复杂机制。References:Lyu P, Agarwal G, Guo C J, et al. Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells[J]. Cell, 2026.前往小宇宙评论区与主播互动
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995-HOTSCRAMBL：调控造血干细胞自稳态的长链非编码RNA
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