A diversified memory repertoire from a single naive T cell

 Hello In this edition of the podcast I will discuss a paper published by Stemberger and collaborators in the journal Immunity called "A single naive CD8+ T cells precursor can develop into diverse effector and memory subset" vol 27, pag 987 of December 2007. In this very interesting paper the authors redraw the concepts of memory T cells differentiation from naive T cells, developping a successfull model of transfer of an single naive T cell precursor. The paper shows that this single antigen specific naive T cell precursor can give rise to an diversified memory T cell responses including all subsets (central memory (CD62L positive, CD127 posit) and effector memory (CD62L negative, CD127 positive) T cells) upon antigen challenge. Importantly the kind of memory responses were equivalent in frequency to the ones generated by the host mice (containing a normal size naive pool of antigen specific T cells) against an antigenic protein. See you next time. PS: The audio has "clicks" artifacts that I don't know the origin. I apologize for that.