A novel approach for finding predictive biomarkers
from The Effective Statistician - in association with PSI Hosted by Alexander Schacht and Benjamin Piske, biometricians, statisticians and leaders in the pharma industry
In this episode, I’m joined by Julia Geronimi from Servier and Dr. Pavel Mozgunov from the University of Cambridge to explore a topic that’s absolutely central to advancing precision medicine—predictive biomarkers. We dive into the challenges of identifying predictive vs. prognostic biomarkers, especially in early-phase clinical trials with limited sample sizes. What makes their approach so exciting is that it offers a model-flexible, visually intuitive way to detect predictiveness—even before we talk about dichotomizing biomarkers or setting cutoffs. If you work on clinical trial design, translational science, or biomarker development, this conversation will give you fresh tools—and a lot to think about.
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