A Paradigm Change in Biology

essays.debugyourpain.com## Timestamps00:00:00 Introduction - The Coming Paradigm Change in Biology  00:02:00 The Biomedical Paradigm: Materialism, Reductionism, and Dualism  00:05:00 How Pain Is Usually Explained (And Why It's Wrong)  00:07:00 Problems with Materialism, Reductionism, Dualism00:12:00 Pain Without Damage, Damage Without Pain  00:15:00 The Alternative: Biological Computation and Collective Intelligence. 00:26:00 Health as Problem-Solving Ability, Not Statistical Norms  00:30:00 Pain as a Control Signal and Skill  00:32:00 The Somatic Scientists - Ida Rolf, Moshe Feldenkrais, FM Alexander  00:37:00 Why RCTs Don't Work for Complex Therapies  00:42:00 Bridging Science and Practice ## Key Figures Mentioned- **Michael Levin** (Tufts) - Biological computation and collective intelligence- **Karl Friston** (University College London) - Active inference and free energy principle- **Dennis Noble** (Oxford) - Biological relativity and heart pacemaker cells- **Ida Rolf** - Developed Rolfing, emphasized fascia connections- **Moshe Feldenkrais** - Physicist turned movement therapist- **FM Alexander** - Alexander Technique founderResources- Ashar, Yoni K., et al. "Effect of pain reprocessing therapy vs placebo and usual care for patients with chronic back pain: a randomized clinical trial." JAMA psychiatry 79.1 (2022): 13-23.- Noble, Denis. "A theory of biological relativity: no privileged level of causation." Interface focus 2.1 (2012): 55-64.- Wampold, Bruce E., and Zac E. Imel. The great psychotherapy debate: The evidence for what makes psychotherapy work. Routledge, 2015.- Beyond Biomechanics: The Enactive Inference Approach to Health and Movement: https://osf.io/preprints/psyarxiv/uqcs4_v1About the HostMax is a former machine learning researcher who pivoted to studying pain and cognition after experiencing chronic pain during graduate school. He now uses computational tools to study chronic pain at MIT.---- Substack: debugyourpain.substack.com**Get in touch:**- Email: [email protected] Twitter: @mxslk- Substack: debugyourpain.substack.com This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit essays.debugyourpain.com