AAIC 2021 – Aduhelm Recommendations + Pfizer’s Expanded Chantix Recall

In this episode, Ayesha discusses a set of recommendations for use of the new FDA-approved Alzheimer’s treatment Aduhelm (aducanumab) published by an expert panel, which was shared at the Alzheimer’s Association International Conference (AAIC) 2021 this week. Ayesha and the team talked about the controversial approval of the drug, with lingering questions about its clinical benefit despite having the ability to reduce amyloid plaques as an anti-amyloid monoclonal antibody. It appears that clinicians and scientists in the field have embraced the treatment for the most part and are working towards developing clear guidelines and an infrastructure for the drug’s use in the goal of helping patients that could most benefit from the treatment. The team also talked about Pfizer’s expanded recall of its smoking cessation drug Chantix, which now involves 12 lots. The recall is over the finding of higher than acceptable levels of a potentially carcinogenic nitrosamine in the batches of Chantix tablets produced between 2019 and 2021. Pfizer and the FDA maintain that the benefit of the medication outweighs the risks and that patients should continue using the drug, which is intended for short-term use. Long-term exposure to high amounts of nitrosamines has been linked to cancer-causing effects. The team talked about the increasing findings of impurities in drug manufacturing leading to similar recalls for other drugs recently, and how pharmacists and care providers should be more informed about them to help patients navigate the recalls. Read the full articles here:  AAIC 2021 Coverage: Expert Panel Unveils Recommendations for Biogen’s Aduhelm Chantix Recall: Pfizer Expands Withdrawal of Smoking Cessation Drug Over Carcinogen Concerns For more life science and medical device content, visit the Xtalks Vitals homepage. Follow Us on Social Media Twitter: @Xtalks Instagram: @Xtalks Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured