ACR 2025: Risk of Proteinuria in Patients With Lupus Nephritis and the Timing of Kidney Biopsy in Patients With SLE

Drs. Petri and Woolfson discuss a simple risk score using autoantibodies, complement, and demographics to predict which SLE patients are most likely to develop proteinuria and lupus nephritis. They also highlight evidence showing that earlier kidney biopsies at lower proteinuria levels, especially in patients with low complement, can detect serious disease sooner and improve outcomes.