Adrenaline, Progesterone & the Stress Response

This podcast discussion focused on the importance of progesterone therapy and its relationship to adrenaline and stress management. Carol Petersen, a recognized expert in bioidentical hormone therapy, explained how progesterone plays a crucial role in balancing insulin, glucose, and adrenaline levels, particularly during menopause and perimenopause. She emphasized that conventional low-dose progesterone treatments often fail because they don't address the underlying hormonal imbalances, and recommended higher doses (300-600 milligrams daily) split throughout the day rather than the standard 100-200 milligrams. The conversation also covered how liver health and detoxification pathways significantly impact progesterone metabolism, with Carol explaining that issues with allopregnenolone clearance can cause drowsiness and other side effects. They discussed the importance of proper dosing, timing, and the need to address underlying liver and gut health issues when implementing hormone therapy.