Age Releated Osteoporosis

This episode explores the distinct pathophysiology, diagnosis, and management of age-related osteoporosis, focusing on cellular mechanisms like osteoblast senescence, inflammaging, and altered RANK-ligand signaling that drive cortical and trabecular decay. The discussion highlights the clinical challenges of secondary hyperparathyroidism, somatopause, and multi-axial hormonal declines in patients over age seventy. Listeners will gain insights into accurately interpreting DXA scores amid degenerative spinal changes, utilizing the FRAX tool, and ruling out secondary causes like multiple myeloma. Finally, the podcast outlines sequential therapeutic strategies, detailing the nuances of long-term bisphosphonate use, denosumab rebound risks, and initiating anabolic agents like romosozumab.