“Age Reversal Is Coming.” Everything You Need To Know - Dr David Sinclair - #1141 episode artwork

EPISODE · Aug 24, 2026 · 2H 5M

“Age Reversal Is Coming.” Everything You Need To Know - Dr David Sinclair - #1141

from Modern Wisdom · host Chris Williamson

Dr David Sinclair is a geneticist, professor at Harvard Medical School, and author. Can human aging actually be reversed? What happens if we treat aging as a disease rather than an inevitability? And how close are scientists to turning age-reversal experiments into medicines that could radically extend our lives? Expect to learn how scientists can reset the age of cells without causing cancer, whether resveratrol and NAD supplements actually work, why three meals a day plus snacks might be marketing, the best exercise protocol for longevity, whether GLP-1s are legitimate longevity drugs, and much more... Sponsors: See discounts for all the products I use and recommend: ⁠https://chriswillx.com/deals⁠ Get a free bottle of D3K2, an AG1 Welcome Kit, and more when you first subscribe at https://ag1.info/modernwisdom Get up to 20% off Timeline’s leading longevity and cellular health supplement at https://timeline.com/modernwisdom Get 160+ lab tests for just $365 and save an extra $25 at https://functionhealth.com/modernwisdom Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get ChatGPT to explore ideas, solve problems, and learn faster at ⁠https://chatgpt.com Timestamps: (0:00) How David’s Work Has Evolved(0:58) Can Scientists Actually Reverse Blindness?(5:53) How Does ER100 Work?(8:57) Is Aging a Disease?(10:14) What’s Next in Age Reversal?(14:00) How to Reverse Aging Without Going Too Far(17:10) What Most Longevity Experts Secretly Believe(20:48) The Biggest Levers for Reversing Aging(22:53) Can We Survive 2 Weeks Without Food?(32:55) The Most Effective Way to Fast(36:10) Does Calorie Restriction Actually Extend Human Life?(40:52) Is the Proteinmaxxing Movement Overhyped?(44:41) Could Sex Help You Live Longer?(47:57) Why Quality Sleep Is Essential for Longevity(51:01) Can Overthinking Shorten Your Lifespan?(55:05) What Longevity Drugs Does David Take Every Day?(56:48) The Truth Behind Controversial Longevity Drugs(1:13:51) Can Erectile Dysfunction Medication Treat Cancer?(1:17:46) The Hidden Danger of Heavy Metals in Supplements(1:21:45) The Benefits of Creating a Longevity Community(1:24:54) Sauna vs Cold Plunges: Which Is Better for Longevity?(1:31:34) Is Bryan Johnson’s Protocol Actually Working?(1:35:39) Are Vitamins a Waste of Money?(1:39:41) Could GLP-1s Protect Against Dementia?(1:46:23) What’s AI Doing to Longevity Research?(1:54:30) Can Your Mindset Affect How Long You Live?(1:56:55) The Two Things That Matter Most for Longevity(1:58:01) Which Longevity Methods Actually Work?(2:03:31) When Health Optimisation Goes Too Far(2:05:18) Where to Find David Extra Stuff: Get my free reading list of 100 books to read before you die: ⁠https://chriswillx.com/books⁠ Try my productivity energy drink Neutonic: ⁠https://neutonic.com/modernwisdom⁠ Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: ⁠lnkfi.re/SN-Goggins⁠ #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: ⁠lnkfi.re/SN-Peterson⁠ #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: ⁠lnkfi.re/SN-Huberman⁠ - Get In Touch: Instagram: ⁠https://www.instagram.com/chriswillx⁠ Twitter: ⁠https://www.twitter.com/chriswillx⁠ YouTube: ⁠https://www.youtube.com/modernwisdompodcast⁠ Email: ⁠https://chriswillx.com/contact⁠ - Learn more about your ad choices. Visit megaphone.fm/adchoices

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