AI:AM — Build, Measure, Heal: AI's Three Frontiers · June 4, 2026

Today on AI:AM — “Build, Measure, Heal: AI’s Three Frontiers.”We open on the AI CEOs’ call to make DNA-synthesis screening law and what cheap intelligence does to biosecurity, then OpenAI’s new Sites product and the platform playbook of absorbing the app layer, the data-center and chip land grab, and why a fresh open model from NVIDIA still trails Anthropic’s best by a wide margin.Hooman Radfar (Collective) on building the autonomous finance department for America’s 30 million solopreneurs — how one bookkeeper now supports 250 clients, why the app layer can still defend its margins against the frontier labs, why “Anthropic is like a drug dealer” on token costs, and why the real thing to regulate is the model arms race.Taras Pohrebniak (Elomia Health) on agentic AI for mental health — an architecture that spends most of its compute on safety, why the company deliberately avoids hyper-realistic voice, where the regulatory line sits between a “friend” app and a medical device, and what they learned deploying in US prisons and on Ukraine’s front lines.Peter Jansen (Ai2) on whether AI can actually do science — the leap from fourth-grade science benchmarks to the Theorizer project, why evaluating machine-generated theories is the real bottleneck, the cautionary tale of a “discovery” that turned out to analyze a random-number generator, and why benchmarks like ScienceWorld still break the best models.We close on the inversion of the scientific method into a data-first discipline, what interpretability could add, and why biology’s data scarcity — not algorithms — may be the binding constraint on curing disease. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit briefing.ai-in-the-am.com