EPISODE · Feb 3, 2026 · 55 MIN
AI and Leadership Playbook from U.S. Bank’s CIO | Mo Jamous | EP 119
from Leading Minds Revealed · host Michael Apollo
In this episode of Leading Minds Revealed, host Michael Apollo sits down with Mo Jamous, Chief Information Officer at U.S. Bank, for a deeply human conversation on leadership, purpose, and AI-driven transformation. Mo shares how purpose becomes an anchor during uncertainty, why technology should be used to empower—not replace—people, and how leaders can stay grounded while navigating rapid, overlapping waves of change. Drawing from decades of experience across digital, cloud, and AI transformations, Mo offers practical insight into building customer-obsessed cultures, introducing AI responsibly, and leading with clarity in moments of disruption. This episode is a powerful exploration of future-ready leadership, human-centered technology, and the mindset required to create lasting impact in an AI-driven world. Guest: Mo Jamous, Chief Information Officer, U.S. Bank Host: Michael Apollo ⏱️ Timestamps 00:00 – Welcome to Leading Minds Revealed 00:55 – Episode focus: leading with purpose in transformation 01:37 – Introducing Mo Jamous, CIO of U.S. Bank 02:27 – Why purpose matters most during uncertainty 03:28 – Mo’s early story and discovering his leadership “why” 05:40 – Purpose as the constant through transformation 07:25 – Translating mission into daily leadership behaviors 08:35 – Staying grounded through customer feedback 09:16 – Turning personal habits into organizational culture 10:38 – What customer obsession looks like in practice 12:04 – Avoiding “shiny object” syndrome in AI 13:44 – Being intentional with innovation 15:22 – AI as empowerment, not replacement 17:54 – Addressing fear and misinformation around AI 19:19 – Creating value vs. cutting costs with AI 21:21 – Separating hype from reality in AI narratives 23:08 – Task-based work and human-AI collaboration 24:19 – Leadership principles that stay constant 26:40 – Psychological safety, collaboration, and trust 28:58 – Is AI fundamentally different from past tech waves? 30:39 – Why AI adoption lags behind capability 33:00 – Upskilling teams and AI literacy challenges 35:53 – Helping teams change how they work 38:22 – Progressive AI rollout strategies 40:32 – Human-centered change leadership 41:22 – Being present as a leader during uncertainty 43:28 – Recognition, visibility, and employee motivation 45:57 – How service shaped Mo’s leadership philosophy 48:38 – Is digital transformation really human transformation? 49:06 – Advice for leaders navigating AI-driven change 52:35 – Where to follow Mo Jamous 54:20 – Final reflections and closing 📣 Call to Action If this conversation resonated with you, subscribe to Leading Minds Revealed, like this episode, and share it with a leader navigating change. Leave a comment with your biggest takeaway—we’d love to hear your perspective.
What this episode covers
In this episode of Leading Minds Revealed, host Michael Apollo sits down with Mo Jamous, Chief Information Officer at U.S. Bank, for a deeply human conversation on leadership, purpose, and AI-driven transformation. Mo shares how purpose becomes an anchor during uncertainty, why technology should be used to empower—not replace—people, and how leaders can stay grounded while navigating rapid, overlapping waves of change. Drawing from decades of experience across digital, cloud, and AI transformations, Mo offers practical insight into building customer-obsessed cultures, introducing AI responsibly, and leading with clarity in moments of disruption. This episode is a powerful exploration of future-ready leadership, human-centered technology, and the mindset required to create lasting impact in an AI-driven world. Guest: Mo Jamous, Chief Information Officer, U.S. Bank Host: Michael Apollo ⏱️ Timestamps 00:00 – Welcome to Leading Minds Revealed 00:55 – Episode focus: leading with purpose in transformation 01:37 – Introducing Mo Jamous, CIO of U.S. Bank 02:27 – Why purpose matters most during uncertainty 03:28 – Mo’s early story and discovering his leadership “why” 05:40 – Purpose as the constant through transformation 07:25 – Translating mission into daily leadership behaviors 08:35 – Staying grounded through customer feedback 09:16 – Turning personal habits into organizational culture 10:38 – What customer obsession looks like in practice 12:04 – Avoiding “shiny object” syndrome in AI 13:44 – Being intentional with innovation 15:22 – AI as empowerment, not replacement 17:54 – Addressing fear and misinformation around AI 19:19 – Creating value vs. cutting costs with AI 21:21 – Separating hype from reality in AI narratives 23:08 – Task-based work and human-AI collaboration 24:19 – Leadership principles that stay constant 26:40 – Psychological safety, collaboration, and trust 28:58 – Is AI fundamentally different from past tech waves? 30:39 – Why AI adoption lags behind capability 33:00 – Upskilling teams and AI literacy challenges 35:53 – Helping teams change how they work 38:22 – Progressive AI rollout strategies 40:32 – Human-centered change leadership 41:22 – Being present as a leader during uncertainty 43:28 – Recognition, visibility, and employee motivation 45:57 – How service shaped Mo’s leadership philosophy 48:38 – Is digital transformation really human transformation? 49:06 – Advice for leaders navigating AI-driven change 52:35 – Where to follow Mo Jamous 54:20 – Final reflections and closing 📣 Call to Action If this conversation resonated with you, subscribe to Leading Minds Revealed, like this episode, and share it with a leader navigating change. Leave a comment with your biggest takeaway—we’d love to hear your perspective.
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AI and Leadership Playbook from U.S. Bank’s CIO | Mo Jamous | EP 119
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