Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation

Send us Fan MailAlbee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications: [01:45]       A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells                  Stem Cell Reports 18, 1701-1720 (2023)[includes new iPS cell line from an individual with Alexander disease] [full text][05:39]       Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational ModificationsJournal of Visualized Experiments 18, 55655 (2017)[includes data on acetylation of lysines in GFAP] [full text][10:26]       STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease                  Cells 12, 978 (2023)[identification of one of the key mechanisms responsible for the increase in GFAP levels in Alexander disease] [full text][22:35]       Questions from email: does Alexander disease affect menstrual cycles?Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:          https://alexander-disease.waisman.wisc.edu/donate/