Alexander Disease Research Update – Episode #27: Genotype-phenotype association for 14 GFAP variants

Send us Fan MailAlbee Messing, Mel Feany, and Natasha Snider discuss the following recent publication: Genotype-phenotype association for 14 GFAP variants in Alexander disease. Neurology: Genetics. 11, e200270 (2025) [full text] Send your questions and feedback to:  [email protected] support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:           https://alexander-disease.waisman.wisc.edu/donate/    1.      Berman RF, Matson MR, Bachman AM, Lin N-H, Coyne S, Frelka A, et al. GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease. eNeuro:(in press) (2025) PMID: 40064497 Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications J Vis Exp, 18, 55655 (2017)STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease Cells, 12, 978 (2023)A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells Stem Cell Reports, 18, 1701-1720 (2023)