EPISODE · Aug 18, 2026 · 25 MIN
Alexander Shulgin: The Chemist Who Rediscovered MDMA
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Alexander Sasha Shulgin was a Harvard-educated biochemist who synthesized and personally tested more than 200 psychoactive compounds. A strange 1944 placebo experience with sugar-laced orange juice hinted at his lifelong fascination with the mind.This episode follows his path from Dow Chemical, where he invented a blockbuster pesticide, to a backyard laboratory, a federal research license, and the publication that ended his career.Inventing the pesticide sold as Zectran, which funded his research freedomDiscovering DOM and the STP public health crisis in San FranciscoHolding a Schedule I license while consulting for the DEAReintroducing and resynthesizing the forgotten molecule MDMA in 1976Publishing PIHKAL, the 1994 farm raid, and his cognitive liberty stance
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Alexander Shulgin: The Chemist Who Rediscovered MDMA
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