Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype

Dr Kirsty McHugh and Dr Carolyn Nielsen discuss a recent Cell article: ‘Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype’. This episode discusses the following article: Barrett, J et al., Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype. Cell 187 (5 September 2024). https://doi.org/10.1016/j.cell.2024.06.015 Article funding and acknowledgments: https://www.sciencedirect.com/science/article/pii/S009286742400655X?via%3Dihub#ack0010 The paper discussed in this episode is the product of six years of work with important contributions made by many members of Prof Simon Draper’s blood-stage malaria team, as well as key external collaborators. Dr McHugh and Dr Nielsen would like to thank all authors for their input, in particular Jordan Barrett as first author, Dimitra Pipini for antibody expression, Giacomo Gorini as the early phase project lead, Nathan Wright for the structural work, and Brandon Wilder for the mouse model. USAID was the major funder. Full author list: Jordan R Barrett, Dimitra Pipini, Nathan D Wright, Andrew J R Cooper, Giacomo Gorini, Doris Quinkert, Amelia M Lias, Hannah Davies, Cassandra A Rigby, Maya Aleshnick, Barnabas G Williams, William J Bradshaw, Neil G Paterson, Thomas Martinson, Payton Kirtley, Luc Picard, Christine D Wiggins, Francesca R Donnellan, Lloyd D W King, Lawrence T Wang, Jonathan F Popplewell, Sarah E Silk, Jed de Ruiter Swain, Katherine Skinner, Vinayaka Kotraiah, Amy R Noe, Randall S MacGill, C Richter King, Ashley J Birkett, Lorraine A Soisson, Angela M Minassian, Douglas A Lauffenburger, Kazutoyo Miura, Carole A Long, Brandon K Wilder, Lizbé Koekemoer, Joshua Tan, Carolyn M Nielsen, Kirsty McHugh* and Simon J Draper*. *Joint senior authors.