Analytical Concordance of Diverse Point-of-Care and Central Laboratory Troponin I Assays

Cardiac troponin is the supreme biomarker for the diagnosis of acute myocardial infarction.  The ability of the clinical laboratory to provide rapid and reliable troponin results is critical for patient management in the emergency room.  In clinics and environments far from a laboratory, point-of-care troponin testing may be necessary for timely results and patient triage.  However, questions remain about the concordance among point of care and laboratory-based methods and whether the same result cut-offs should be used for clinical decision making. A study published in the March 2019 issue of The Journal of Applied Laboratory Medicine investigates the analytical concordance of three point-of-care cardiac troponin I assays against the added high sensitivity troponin I assay.