Anthropic's Alignment Lead Says AI Might Kill Us All

Anthropic's alignment lead put a 10% number on human extinction within a decade, and Nick and Jack dig into what that means: why quantifying the risk matters, whether it helps or hurts Anthropic's trust and its IPO, and the Manhattan Project parallels. Then the good news: DeepMind's AlphaGenome Atlas just scored all 9 billion single-letter DNA changes, AI-generated age-reversal drugs are in trials, and longevity is starting to look like a solvable problem. Also covered: ChatGPT Images 2.5, whether we already hit AGI, the Stacked Mac mini giveaway, smart glasses, and running local models on a Mac. Watch on YouTube: https://youtu.be/feCnrRXZRss Check out Higgsfield, one of our sponsors: https://bit.ly/4gEW43Z Inquiries: reach out to [email protected]

Episode metadata supplied by the publisher feed · Published Sep 9, 2026

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Anthropic's Alignment Lead Says AI Might Kill Us All

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