Antimicrobial Pharmacodynamics in Theory and Clinical Practice

A book discussing antimicrobial pharmacodynamics (PD), focusing on how drug concentrations relate to therapeutic effects against various pathogens. The content covers general concepts like pharmacokinetic/pharmacodynamic (PK/PD) indices (e.g., AUC/MIC, time above MIC) and their application in determining optimal dosing regimens for different classes of drugs, including $\beta$-lactams, aminoglycosides, quinolones, and antifungals. Several sections address the importance of using in vitro and animal models to predict antibiotic efficacy and prevent the emergence of resistance, emphasizing that the most predictive PK/PD parameter varies by antimicrobial agent and infection type. Finally, the text explores regulatory and economic considerations, such as using PD analysis in setting susceptibility breakpoints and performing pharmacoeconomic evaluations.You can listen and download our episodes for free on more than 10 different platforms:https://linktr.ee/pharmacy_simpleProduced by:https://www.podcaistudio.com/