Anxiety, its effect on the body and reality: listener question

Completely understand the importance of where we direct our energy. When experiencing immense bouts of anxiety energy is so misused that the body becomes weak, breathless, shaky, jumpy, nauseous, and fragile. My question is does, or, will this suffering cause any actual harm to our mind or body in the long run? Surely it has an effect on our defenses over time after repeated bouts? This concerns me.