Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

Professor Quentin Sattentau discusses research published in 'Nature Communications' on the role of enzyme ADAM10 in mediating clearance of apoptotic T cells by macrophages. This episode discusses Drexhage, LZ, Zhang, S, Dupont, M, et al. Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nat Commun. 15(1), 541 (2024). http://doi.org/10.1038/s41467-023-44619-8 Article funding and acknowledgments: https://www.nature.com/articles/s41467-023-44619-8#Ack1 Professor Sattentau thanks Linnea Drexhage and Shengpan Zhang (joint first authors) who worked really hard and provided most of the data, Niloofar Karaji who discovered the initial phenomenon, all the other authors for their excellent input, and the MRC for funding the project.