APP Roundtable: Future Directions in PBC Research
from GHAPPcast
In this podcast episode, Future Directions in PBC Research and Management, Christina Hanson, FNP, South Denver Gastroenterology, and Patrick Horne, NP, University of Florida, explore the evolving landscape of Primary Biliary Cholangitis (PBC)—highlighting advances in biomarkers, treatment targets, and personalized care. The conversation addresses a shift in clinical thinking beyond alkaline phosphatase alone, emphasizing the role of additional markers like bilirubin, GGT, albumin, and fibrosis stage in risk stratification and treatment planning. The episode also underscores the importance of symptom assessment, especially for pruritus and fatigue, which are often underreported by patients but have a significant impact on quality of life. With the arrival of new second-line therapies and promising data from IBAT inhibitors and PARS agonists, the hosts highlight how emerging research is transforming patient management in PBC. This episode is a must-listen for clinicians seeking to optimize outcomes with a multimodal, symptom-driven approach and stay ahead of new developments in PBC treatment and clinical trials.
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