ASH 2021 Recap: Multi Omics Sheds New Light on Malignant Transformation from Myeloproliferative Neoplasm to AML

In this episode, we bring you new research from the 2021 American Society of Hematology Annual Meeting about the cellular processes involving the mutated TP53 oncogene that can convert a patient’s—fairly benign—myeloproliferative neoplasm into a very threatening acute myeloid leukemia. These have been under investigation at Oxford University in the UK, using the refined genetic sequencing tool: single cell multi omics (Abstract 3). The ASH Plenary Session heard an inspiring talk on this from Oxford scientist Alba Rodriguez-Meira—winner of an ASH Abstract Achievement Award. And after the session, OT reporter Peter Goodwin tracked down her colleague, senior author Adam J. Meade, at the Weatherall Institute of Molecular Medicine in Oxford University.