ASH 2025 highlights in AL amyloidosis: risk stratification, bispecific antibodies, CAR-T, & MRD

This VJHemOnc podcast highlights key AL amyloidosis updates from ASH 2025, spanning risk stratification, optimisation of frontline therapy, emerging immunotherapies, and MRD assessment. Jahanzaib Khwaja, MD, FRCPath, University College London Hospitals NHS Foundation Trust, London, UK, discusses a newly validated staging system defining ultra-high-risk AL amyloidosis in the era of daratumumab-based therapy. Vaishali Sanchorawala, MD, Boston University School of Medicine, Boston, MA, presents Phase II AQUARIUS trial (NCT05250973) data evaluating daratumumab-VCd dosing in newly diagnosed disease and shares Phase I trail (NCT06158854) results of the BCMA x CD3 bispecific antibody etentamig in relapsed or refractory AL amyloidosis. Heather Landau, MD, Memorial Sloan Kettering Cancer Center, New York, NY, reviews early results from the NEXICART-2 trial (NCT06097832) of the BCMA-directed CAR T-cell therapy NXC-201. Andrew Staron, MD, Boston Medical Center, Boston, MA, discusses the prognostic significance of sustained MRD negativity, while Matthew Rees, MD, St. Vincent’s Hospital, Melbourne, Australia, presents real-world data on BCMA-directed CAR T-cell and bispecific therapies in systemic AL amyloidosis.