Asthma: From Trigger to Treatment

In this week's episode, we’re using a historical naval mishap as a metaphor to explain how asthma works. Much like the Spanish ships accidentally firing on their own allies in 1801, asthma is caused by your immune system misfiring—targeting harmless particles like dust or allergens and causing inflammation in your airways. We’ll dive into the mechanics of asthma, explore the role of the immune system’s cytokines and white blood cells, and look at the latest treatments and research aimed at calming this immune overreaction.Participate in clinical research!www.ENCOREdocs.comShare with a friend. Rate, Review, and Subscribe to the ENCORE Research Group podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence podcast. www.MedEvidence.comThank you for listening!References:American Lung Association. (2024, June 7). What causes asthma?  https://www.lung.org/lung-health-diseases/lung-disease-lookup/asthma/learn-about-asthma/what-causes-asthmaCenters for Disease Control and Prevention (CDC). (2023, May 10). Most recent national asthma data. https://www.cdc.gov/asthma/most_recent_national_asthma_data.htmCollaborators, G. B. D. (2018). Global, regional, and national incidence, prevalence... https://doi.org/10.1016/S0140-6736(18)32279-7Ebina-Shibuya, R., & Leonard, W. J. (2023). Role of thymic stromal lymphopoietin in allergy and beyond. https://www.nature.com/articles/s41577-022-00735-yHamid, Q., & Tulic, M. (2009). Immunobiology of asthma. Annual review of physiology, 71(1), 489-507. https://doi.org/10.1146/annurev.physiol.010908.163200Keats, R.G. (1801, August 3). Superb off Cape Trafalgar, June 13, 1801. The London Gazette. https://www.thegazette.co.uk/London/issue/15392/page/946Koren, M.J. & Joshi, S. (Hosts). (2023). Two docs talk allergies and asthma. [Podcast Episode]. In MedEvidence! Truth Behind the Data. MedEvidence. https://medevidence.com/two-docs-talk-allergy-and-asthma-part-1World Health Organization. (2024, May 6). Asthma. [Website]. Accessed 3 September 2024. https://www.who.int/news-room/fact-sheets/detail/asthmaYang, D., Han, Z., & Oppenheim, J. J. (2017). Alarmins and immunity. Immunological reviews, 280(1), 41-56. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699517/Ying, S., O’Connor, B., Ratoff, J., Meng, Q., Mallett, K., Cousins, D., ... & Corrigan, C. (2005). Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. The Journal of Immunology, 174(12), 8183-8190.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!