Astrocyte-neuron signaling in the mesolimbic dopamine system: the hidden stars of dopamine signaling

Star-shaped cells called astrocytes are the most abundant cells to be found in the human brain. In the past, they’d been thought to play a supporting role to neurons, such as providing metabolic support, but recently they’re also emerging as stars of information processing. They can respond to neurotransmitters and release neuroactive substances that then affect synaptic transmission and plasticity. Michelle Corkrum is a child neurology resident at Columbia University and is one of the authors of a recent review paper on the links between astrocytes and dopamine signalling. The review looks back at the history of research in this field, going back decades. Listen in to learn more!