Battle for Lightweight Championship! Tirzepatide vs Semaglutide Head to Head for Weight Loss

Title: Tirzepatide vs Semaglutide: Which GLP-1 Wins? | SURMOUNT-5 TrialDescription:Head-to-head comparison: tirzepatide 15mg vs semaglutide 2.4mg for weight loss. SURMOUNT-5 trial breakdown in under 5 minutes. Evidence-based medicine, no fluff.📊 KEY FINDINGS:Tirzepatide: -20.2% weight loss at 72 weeksSemaglutide: -13.7% weight loss at 72 weeks48.4% vs 27.3% achieving ≥20% weight lossSimilar tolerability (6.1% vs 8.0% discontinuations)Tirzepatide superior for weight reduction📚 CITATION:Aronne LJ, Horn DB, le Roux CW, et al. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity. N Engl J Med. 2025;393:26-36.DOI: 10.1056/NEJMoa2416394🎓 ABOUT:Gregory Castelli, PharmD, FCCP, BCPS, BC-ADM, CDCESAssociate ProfessorDirector of Academic and Clinical PharmacyEditor-in-Chief, PURL SeriesDispense As Written delivers evidence-based medicine for busy clinicians—without the fluff.