Berberine was a dye before it was a supplement and that might explain its mechanism

Berberine's intense yellow color comes from its ability to intercalate into DNA. It literally slides between DNA base pairs. This same property explains its anti-microbial and anti-cancer mechanisms and also why it inhibits CYP3A4 (the same enzyme that metabolizes 50% of all drugs). The supplement industry rarely mentions that the same molecule that lowers blood sugar also creates significant drug interactions in ~30% of users.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/22316074/https://pubmed.ncbi.nlm.nih.gov/21870106/ https://pubmed.ncbi.nlm.nih.gov/34269665/