Berberine's GLP-1 mechanism isn't what influencers think it is

The "nature's Ozempic" claim is based on AMPK activation, an indirect, downstream effect. But berberine (specifically dihydroberberine) appears to directly stimulate GLP-1 secretion from intestinal L-cells through a separate, AMPK-independent pathway. The real GLP-1 story is actually more compelling than the marketing claim, but it requires a mechanistic understanding most companies don't have. That mechanism is patentable.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/38351702/https://pmc.ncbi.nlm.nih.gov/articles/PMC6155143/https://pubmed.ncbi.nlm.nih.gov/34481875/